Study Warns That Pfizer’s Vaccine May Be Less Effective if You’re Fat Because Obese People Only Make Half as Many Antibodies

Pfizer’s Covid vaccine may be less effective if you’re fat, a study has warned.

Italian researchers said obese people make half as many antibodies – proteins that attack the virus.

It may be because their fat hampers their immune system, which is involved in making antibodies.

Extra weight can cause long-term inflammation, which sabotages the immune system and makes it less able to fight infection.

Obesity, defined as a BMI over 30, has already been shown to be a risk factor for severe Covid and death, prompting health officials to warn the public to drop some pounds.

But the exact reasons have not been clearly explained.

The latest study was conducted by Dr Aldo Venuti, of the Istituti Fisioterapici Ospitalieri in Rome, and colleagues.

The team looked at how many antibodies were produced after two doses of the Pfizer/BioNTech vaccine in 248 healthcare workers – of which only 26 were classed as obese, making it a small study.

Seven days after receiving the second dose, 99.5 per cent of people had developed an antibody response that was able to fight the virus.

The response was greater in those who were slim, while blunted in those who were fat – even after accounting for age, which can also dampen antibody response.

Those who were a normal BMI range had an average antibody concentration of 325.8 compared to 167.1 in obese people.

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Source: the Sun