Lafayette Fire Chief Robert Benoit confirmed to KLFY that there were five fatalities at the scene and one survivor.
He said at least three people not affiliated with the plane were transported to the hospital. Their conditions were not immediately known.
The plane crashed in a parking lot near a Walmart and U.S. Post Office building in Lafayette, at the intersection of Verot School Road and Feu Follet.
Lafayette Police Lt. Scott Morgan told Fox News the incident took place at 9:22 a.m. local time after the aircraft departed from Lafayette Regional Airport.
Details on the reason for the crash were not immediately available.
Acadian Ambulance said on Twitter that they transported two patients to local hospitals in unknown condition.
The Federal Aviation Administration said the aircraft was a Piper-Cheyenne Fixed Wing Multi-Engine Aircraft registered to Cheyenne Partners LLC, based out of Lafayette. It had eight seats and two engines.
Information on Flightaware.com showed the aircraft took off from Lafayette airport at 9:20 a.m. and was headed to DeKalb-Peachtree Airport near Atlanta, Georgia. According to the site, the aircraft reached a speed of around 192 mph and reached an altitude of 375 feet before crashing.
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Source: Fox News